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Contraindicated (1)pentobarbital will minimize the level or result of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is responsible for the formation and elimination of cariprazine's Energetic metabolites.pentobarbital will lessen the extent or impact of ibuprofen by influencing hepatic enzyme CYP2C9/t